Enter "An Abandoned Shack" at 5,4. Go through the trapdoor.
To find the majority of the Giant Spiders and Spidra Arcana, try going as north east as you can.
You'll find a chasm, enter it.
(UPDATE: there is a portal that takes you there directly at 11,13 - Backward Lane)
Description: This brutish female creature seems more serpent than humanoid. The long powerful tail and leathery wings pale in comparison to the writhing nest of vipers on its head.